Two years from the first use. After 2 years, the nylon ring inside Caya loses its “bounce back,” which can make it less effective. We recommend you write the date of first-use on the box, or put a note in your calendar to order a new one earlier than 2 years from the first-use date. Any Caya diaphragm older than 2 years, no matter how often it was used, should be discarded.